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"Analysis on the myosin-II-responsive focal adhesion proteome reveals a role for beta-Pix in negative regulation of focal adhesion maturation."
This subsection in the Sequence portion signifies Should the canonical sequence shown by default in the entry is in its mature kind or if it signifies the precursor.Additional...Sequence processingi: The shown sequence is further processed into a mature kind.
This subsection of your 'Pathology and Biotech' area presents info on the sickness(s) related to genetic variations in a very specified protein.
Knocking down βone integrin inhibited most cancers cell migration, Whilst overexpressing the integrin in Cdc42-deficient cells restored endothelial invasion.[ten] Cdc42 promoted β1 integrin expression by activating a transcription issue named SRF. A continuously Energetic sort of the transcription component was also able to restoring endothelial insertion to cancer cells missing Cdc42.
"Macrothrombocytopenia and developmental hold off using a de novo CDC42 Get More Info mutation: Yet one more locus for thrombocytopenia and developmental hold off."
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This area shows by default the canonical protein sequence and on ask for all isoforms described while in the entry. In addition it involves facts pertinent towards the sequence(s), together with length and molecular body weight.
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"The composition of Staufen-containing RNA granules from human cells indicates their role in the controlled transport and translation of messenger RNAs."
It should be famous that though, in theory, two different sequences might have precisely the same checksum worth, the chance that this would come about is amazingly reduced.
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Involved in epithelial mobile polarization procedures. Regulates the bipolar attachment of spindle microtubules to kinetochores in advance of chromosome congression in metaphase (PubMed:15642749).
The annotation rating delivers a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score can't be utilized for a measure from the precision of your annotation as we simply cannot outline the 'appropriate annotation' for any supplied protein.
Consume one bottle of ISOTECH 42â„¢ just before through or following a exercise routine. Will also be eaten on non-instruction days.